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Article

Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.

PloS one - 1 Jan 2013

Scaramuzzino Chiara, Monaghan John, Milioto Carmelo, Lanson Nicholas A, Maltare Astha, Aggarwal Tanya, Casci Ian, Fackelmayer Frank O, Pennuto Maria, Pandey Udai Bhan

Abstract excerpt

Amyotrophic lateral sclerosis (ALS) is a late onset and progressive motor neuron disease. Mutations in the gene coding for fused in sarcoma/translocated in liposarcoma (FUS) are responsible for some cases of both familial and sporadic forms of ALS. The mechanism through which mutations of FUS result in motor neuron degeneration and loss is not known. FUS belongs to the family of TET proteins, which are regulated...

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Source

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Identifiers

PMID: 23620769
DOI: 10.1371/journal.pone.0061576
PMCID: PMC3631215

Genes

FUS
PRMT1
PRMT8

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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Protein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.PMID 23620769Read ↗

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