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Article

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.

Acta neuropathologica - 1 Nov 2012

Neumann Manuela, Valori Chiara F, Ansorge Olaf, Kretzschmar Hans A, Munoz David G, Kusaka Hirofumi, Yokota Osamu, Ishihara Kenji, Ang Lee-Cyn, Bilbao Juan M, Mackenzie Ian R A

Abstract excerpt

Accumulation of the DNA/RNA binding protein fused in sarcoma (FUS) as inclusions in neurons and glia is the pathological hallmark of amyotrophic lateral sclerosis patients with mutations in FUS (ALS-FUS) as well as in several subtypes of frontotemporal lobar degeneration (FTLD-FUS), which are not associated with FUS mutations. Despite some overlap in the phenotype and neuropathology of FTLD-FUS and ALS-FUS,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heterogeneous Nuclear Ribonucleoprotein A1

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Share to RNA-Binding Protein EWS

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Source

Identifiers

PMID: 22842875
DOI: 10.1007/s00401-012-1020-6

Genes

FUS
TAF15

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

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Research trail→

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Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.PMID 22842875Read ↗

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.Semantic proximity Read ↗

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUSSemantic proximity Read ↗

Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: molecular similarities and differences.Semantic proximity Read ↗

Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions.Semantic proximity Read ↗

Importance of Functional Loss of FUS in FTLD/ALSSemantic proximity Read ↗

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

FUS‐Immunoreactive Intranuclear Inclusions in Neurodegenerative DiseaseSemantic proximity Read ↗

FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damage.Semantic proximity Read ↗

ALS mutant FUS disrupts nuclear localization and sequesters wild-type FUS within cytoplasmic stress granules.Semantic proximity Read ↗

A new subtype of frontotemporal lobar degeneration with FUS pathology.Semantic proximity Read ↗

Fused in sarcoma (FUS) protein lacking nuclear localization signal (NLS) and major RNA binding motifs triggers proteinopathy and severe motor phenotype in transgenic mice.Semantic proximity Read ↗

RNA Binding Protein TAF15 Suppresses Toxicity in a Yeast Model of FUS ProteinopathySemantic proximity Read ↗

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