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Article

Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions.

Journal of neuropathology and experimental neurology - 21 Feb 2023

Honda Hiroyuki, Yoshimura Motoi, Arahata Hajime, Yagita Kaoru, Sadashima Shoko, Hamasaki Hideomi, Shijo Masahiro, Koyama Sachiko, Noguchi Hideko, Sasagasako Naokazu

Abstract excerpt

Fused in sarcoma (FUS), coded by FUS, is a heterogeneous nuclear ribonucleoprotein (hnRNP). FUS mutations are among the major mutations in familial amyotrophic lateral sclerosis (ALS-FUS: ALS6). The pathological hallmarks of ALS-FUS are FUS-positive neuronal cytoplasmic inclusions (NCI). We examined various hnRNPs in FUS NCIs in the hippocampus in ALS-FUS cases with different FUS mutations (Case 1, H517P; Case 2,...

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PMID: 36592411
DOI: 10.1093/jnen/nlac124

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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