Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUS

12 Feb 2019

Abstract excerpt

Frontotemporal lobar degeneration (FTLD) is pathologically subdivided based on the presence of particular pathological proteins that are identified in inclusion bodies observed post-mortem. The FTLD-FUS subgroup is defined by the presence of the fused in sarcoma protein (FUS) in pathological inclusions. FUS is a heterogeneous nuclear ribonucleoprotein (hnRNP) protein and a member of the FET (FUS, EWS, TAF15)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyotrophic Lateral Sclerosis Research
Share to Neurogenetic and Muscular Disorders Research
Share to RNA Research and Splicing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 30755280
DOI: 10.1186/s40478-019-0673-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterogeneous nuclear ribonucleoproteins R and Q accumulate in pathological inclusions in FTLD-FUSPMID 30755280Read ↗

Transportin 1 accumulates specifically with FET proteins but no other transportin cargos in FTLD-FUS and is absent in FUS inclusions in ALS with FUS mutations.Semantic proximity Read ↗

Mutated FUS in familial amyotrophic lateral sclerosis involves multiple hnRNPs in the formation of neuronal cytoplasmic inclusions.Semantic proximity Read ↗

FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations.Semantic proximity Read ↗

Frontotemporal lobar degeneration and amyotrophic lateral sclerosis: molecular similarities and differences.Semantic proximity Read ↗

The presence of heterogeneous nuclear ribonucleoproteins in frontotemporal lobar degeneration with FUS-positive inclusionsSemantic proximity Read ↗

Importance of Functional Loss of FUS in FTLD/ALSSemantic proximity Read ↗

FUS‐Immunoreactive Intranuclear Inclusions in Neurodegenerative DiseaseSemantic proximity Read ↗

A new subtype of frontotemporal lobar degeneration with FUS pathology.Semantic proximity Read ↗

Loss of fused in sarcoma (FUS) promotes pathological Tau splicing.Semantic proximity Read ↗

FUS pathology defines the majority of tau- and TDP-43-negative frontotemporal lobar degeneration.Semantic proximity Read ↗

Pathology of three ALS patients with FUS variants, including one likely benign Q23L variant lacking FUS inclusions.Semantic proximity Read ↗

Role of FET proteins in neurodegenerative disorders.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.