Article
A new subtype of frontotemporal lobar degeneration with FUS pathology.
Brain : a journal of neurology - 1 Nov 2009
Neumann Manuela, Rademakers Rosa, Roeber Sigrun, Baker Matt, Kretzschmar Hans A, Mackenzie Ian R A
Abstract excerpt
Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular basis. The neuropathology associated with most FTD is characterized by abnormal cellular aggregates of either transactive response DNA-binding protein with Mr 43 kDa (TDP-43) or tau protein. However, we recently described a subgroup of FTD patients, representing around 10%, with an unusual clinical phenotype and pathology...
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