Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth.

Development (Cambridge, England) - 1 Jan 2007

Naiche L A, Papaioannou Virginia E

Abstract excerpt

Tbx4 is a crucial gene in the initiation of hindlimb development and has been reported as a determinant of hindlimb identity and a presumptive direct regulator of Fgf10 in the limb. Using a conditional allele of Tbx4, we have ablated Tbx4 function before and after limb initiation. Ablation of Tbx4 before expression in the hindlimb field confirms its requirement for limb bud outgrowth. However, ablation of Tbx4...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Count
Share to Embryonic Induction
Share to Fibroblast Growth Factor 10

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hindlimb

Share to Lower Extremity

Share to T-Box Domain Proteins

Share to Tamoxifen

Share to Transgenes

Source

Identifiers

PMID: 17164415
DOI: 10.1242/dev.02712

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Tbx4 is not required for hindlimb identity or post-bud hindlimb outgrowth.PMID 17164415Read ↗

Tbx2 terminates shh/fgf signaling in the developing mouse limb bud by direct repression of gremlin1.Semantic proximity Read ↗

The limb identity gene Tbx5 promotes limb initiation by interacting with Wnt2b and Fgf10.Semantic proximity Read ↗

Tbx5 is essential for forelimb bud initiation following patterning of the limb field in the mouse embryo.Semantic proximity Read ↗

Dual hindlimb control elements in the Tbx4 gene and region-specific control of bone size in vertebrate limbs.Semantic proximity Read ↗

Developmental and transcriptional programs that define the initiation of the forelimbSemantic proximity Read ↗

Loss of Tbx4 blocks hindlimb development and affects vascularization and fusion of the allantois.Semantic proximity Read ↗

The chick limbless mutation causes abnormalities in limb bud dorsal-ventral patterning: implications for the mechanism of apical ridge formation.Semantic proximity Read ↗

T-box gene tbx5 is essential for formation of the pectoral limb bud.Semantic proximity Read ↗

Proximodistal patterning during limb regeneration.Semantic proximity Read ↗

The role of Lbx1 in migration of muscle precursor cells.Semantic proximity Read ↗

Limb mutants: what can they tell us about normal limb development?Semantic proximity Read ↗

Normal limb development in conditional mutants of Fgf4.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.