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Article

SerpinB2 Is Critical to Th2 Immunity against Enteric Nematode Infection

29 Apr 2013

Abstract excerpt

SerpinB2, a member of the serine protease inhibitor family, is expressed by macrophages and is significantly upregulated by inflammation. Recent studies implicated a role for SerpinB2 in the control of Th1 and Th2 immune responses, but the mechanisms of these effects are unknown. In this study, we used mice deficient in SerpinB2 (SerpinB2(-/-)) to investigate its role in the host response to the enteric nematode,...

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PMID: 23630350
DOI: 10.4049/jimmunol.1200293

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