Article
Mast Cells Are Crucial for Induction of Group 2 Innate Lymphoid Cells and Clearance of Helminth Infections.
Immunity - 16 May 2017
Shimokawa Chikako, Kanaya Takashi, Hachisuka Masami, Ishiwata Kenji, Hisaeda Hajime, Kurashima Yosuke, Kiyono Hiroshi, Yoshimoto Tomohiro, Kaisho Tsuneyasu, Ohno Hiroshi
Abstract excerpt
Mast cells are important for eradication of intestinal nematodes; however, their precise mechanisms of action have remained elusive, especially in the early phase of infection. We found that Spi-B-deficient mice had increased numbers of mast cells and rapidly expelled the Heligmosomoides polygyrus (Hp) nematode. This was accompanied by induction of interleukin-13 (IL-13)-producing group 2 innate lymphoid cells...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.