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Echinococcus multilocularis serpin regulates macrophage polarization and reduces gut dysbiosis in colitis

22 Jul 2024

Abstract excerpt

ABSTRACT Helminths serve as principal regulators in modulating host immune responses, and their excretory-secretory proteins are recognized as potential therapeutic agents for inflammatory bowel disease. Nevertheless, our comprehension of the mechanisms underlying immunoregulation remains restricted. This investigation delves into the immunomodulatory role of a secretory protein serpin ( Emu -serpin), within the...

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PMID: 39037247
DOI: 10.1128/iai.00232-24

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