Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies.

doi:10.4049/jimmunol.1203279

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Article

Multiplex B cell characterization in blood, lymph nodes, and tumors from patients with malignancies.

Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 2013

Zirakzadeh A Ali, Marits Per, Sherif Amir, Winqvist Ola

Abstract excerpt

B lymphocytes contribute to immune surveillance, by tumor-specific Abs and Ag presentation to T lymphocytes, but are insufficiently studied in humans. In this article, we report a flow cytometric investigation of B lymphocyte subpopulations in blood, lymph nodes (LNs), and malignant tissues from 20 patients operated on because of advanced solid tumors. The CD19(+) compartment in peripheral blood was essentially...

Topics

Aged
Aged, 80 and over
Amino Acid Sequence
B-Lymphocyte Subsets
B-Lymphocytes
Base Sequence
Female
Gene Rearrangement, B-Lymphocyte
Humans
Immunoglobulin Heavy Chains
Immunoglobulin Variable Region

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunologic Memory

Immunophenotyping

Lymph Nodes

Lymphocyte Activation

Lymphocytes, Tumor-Infiltrating

Male

Middle Aged

Source

Open in PubMed

Identifiers

PMID: 23630345
DOI: 10.4049/jimmunol.1203279

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