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B cell profiles, antibody repertoire and reactivity reveal dysregulated responses with autoimmune features in melanoma

8 Jun 2023

Abstract excerpt

B cells are known to contribute to the anti-tumor immune response, especially in immunogenic tumors such as melanoma, yet humoral immunity has not been characterized in these cancers to detail. Here we show comprehensive phenotyping in samples of circulating and tumor-resident B cells as well as serum antibodies in melanoma patients. Memory B cells are enriched in tumors compared to blood in paired samples and...

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PMID: 37291228
DOI: 10.1038/s41467-023-39042-y

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