Article
Spatiotemporal genomic analysis reveals distinct molecular features in recurrent stage I non-small cell lung cancers.
Cell reports - 12 Jul 2022
Chen Kezhong, Yang Airong, Carbone David P, Kanu Nnennaya, Liu Ke, Wang Ruiru, Nie Yuntao, Shen Haifeng, Bai Jian, Wu Lin, Li Hui, Shi Yanbin, Mok Tony, Yu Jun, Yang Fan, Wu Shuangxiu, Jamal-Hanjani Mariam, Wang Jun
Abstract excerpt
Stage I non-small cell lung cancer (NSCLC) presents diverse outcomes. To identify molecular features leading to tumor recurrence in early-stage NSCLC, we perform multiregional whole-exome sequencing (WES), RNA sequencing, and plasma-targeted circulating tumor DNA (ctDNA) detection analysis between recurrent and recurrent-free stage I NSCLC patients (CHN-P cohort) who had undergone R0 resection with a median...
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