Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers.

BMC medical genomics - 4 Jun 2014

Sun Zhifu, Wang Liang, Eckloff Bruce W, Deng Bo, Wang Yi, Wampfler Jason A, Jang JinSung, Wieben Eric D, Jen Jin, You Ming, Yang Ping

Abstract excerpt

BACKGROUND: Novel and targetable mutations are needed for improved understanding and treatment of lung cancer in never-smokers. METHODS: Twenty-seven lung adenocarcinomas from never-smokers were sequenced by both exome and mRNA-seq with respective normal tissues. Somatic mutations were detected and compared with pathway deregulation, tumor phenotypes and clinical outcomes. RESULTS: Although somatic mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenocarcinoma
Share to Adenocarcinoma of Lung

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Conserved Sequence

Share to DNA, Neoplasm

Share to Gene Regulatory Networks

Share to Kaplan-Meier Estimate

Share to Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 24894543
DOI: 10.1186/1755-8794-7-32
PMCID: PMC4060138

Genes

ATXN2
DHX9
EGFR
KRAS
MYOF
PTPN13
SPTAN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Conserved recurrent gene mutations correlate with pathway deregulation and clinical outcomes of lung adenocarcinoma in never-smokers.PMID 24894543Read ↗

Somatic mutations affect key pathways in lung adenocarcinoma.Semantic proximity Read ↗

Genomic profiling implicates candidate genes and mutagenic pathways driving lung cancer recurrenceSemantic proximity Read ↗

Mapping the hallmarks of lung adenocarcinoma with massively parallel sequencing.Semantic proximity Read ↗

Common cancer-driver mutations and their association with abnormally methylated genes in lung adenocarcinoma from never-smokers.Semantic proximity Read ↗

Distinct gene mutation profiles among multiple and single primary lung adenocarcinomaSemantic proximity Read ↗

The transcriptional landscape and mutational profile of lung adenocarcinoma.Semantic proximity Read ↗

Tumor mutation burden and recurrent tumors in hereditary lung cancerSemantic proximity Read ↗

A High-Dimensional, Deep-Sequencing Study of Lung Adenocarcinoma in Female Never-SmokersSemantic proximity Read ↗

Genome and transcriptome sequencing of lung cancers reveal diverse mutational and splicing events.Semantic proximity Read ↗

EGFR-mutant lung adenocarcinoma harboring co-mutational tumor suppressor genes predicts poor prognosis.Semantic proximity Read ↗

Genetic Alterations in Preinvasive Lung Synchronous Lesions.Semantic proximity Read ↗

Actionable Gene Alterations in Resected Non-Small Cell Lung Cancer: Primary Results From the AGA-R Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.