Article
Serum tryptase correlates with the KIT D816V mutation burden in adults with indolent systemic mastocytosis.
European journal of haematology - 1 Aug 2013
Kristensen Thomas, Broesby-Olsen Sigurd, Vestergaard Hanne, Bindslev-Jensen Carsten, Møller Michael Boe
Abstract excerpt
Systemic mastocytosis (SM) is characterized by the growth of neoplastic mast cells (MCs). Most adults with indolent SM carry the KIT D816V mutation. We recently introduced the D816V+ allele fraction as a disease marker in SM using a sensitive and quantitative KIT D816V mutation analysis that consistently allows mutation detection in peripheral blood (PB) and bone marrow (BM). The D816V+ allele fraction represents...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.