Article
KIT mutation analysis in mast cell neoplasms: recommendations of the European Competence Network on Mastocytosis.
Leukemia - 1 Jun 2015
Arock M, Sotlar K, Akin C, Broesby-Olsen S, Hoermann G, Escribano L, Kristensen T K, Kluin-Nelemans H C, Hermine O, Dubreuil P, Sperr W R, Hartmann K, Gotlib J, Cross N C P, Haferlach T, Garcia-Montero A, Orfao A, Schwaab J, Triggiani M, Horny H-P, Metcalfe D D, Reiter A, Valent P
Abstract excerpt
Although acquired mutations in KIT are commonly detected in various categories of mastocytosis, the methodologies applied to detect and quantify the mutant type and allele burden in various cells and tissues are poorly defined. We here propose a consensus on methodologies used to detect KIT mutations in patients with mastocytosis at diagnosis and during follow-up with sufficient precision and sensitivity in daily...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.