Article
Circulating KIT D816V mutation-positive non-mast cells in peripheral blood are characteristic of indolent systemic mastocytosis.
European journal of haematology - 1 Jul 2012
Kristensen Thomas, Broesby-Olsen Sigurd, Vestergaard Hanne, Bindslev-Jensen Carsten, Møller Michael B
Abstract excerpt
It is presently accepted that the KIT D816V mutation is detectable in tissues with neoplastic mast cells in most patients with indolent systemic mastocytosis. In this study, neoplastic mast cells were detected in bone marrow, but not in peripheral blood, by flow cytometry in all 25 included cases of indolent systemic mastocytosis. However, the KIT D816V mutation was detected using mutation-specific qPCR in both...
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