Article
The KIT D816V allele burden predicts survival in patients with mastocytosis and correlates with the WHO type of the disease.
Allergy - 1 Jun 2014
Hoermann G, Gleixner K V, Dinu G E, Kundi M, Greiner G, Wimazal F, Hadzijusufovic E, Mitterbauer G, Mannhalter C, Valent P, Sperr W R
Abstract excerpt
KIT D816V is present in a majority of patients with systemic mastocytosis (SM). We determined the KIT D816V allele burden by quantitative real-time PCR in bone marrow and peripheral blood of 105 patients with mastocytosis. KIT D816V was detected in 92/105 patients (88%). Significant differences in the median allele burden were observed between disease subgroups: cutaneous mastocytosis (0.042%), indolent SM...
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