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Article

HLA-DPB1 Reactive T Cell Receptors for Adoptive Immunotherapy in Allogeneic Stem Cell Transplantation.

Cells - 20 May 2020

Klobuch Sebastian, Hammon Kathrin, Vatter-Leising Sarah, Neidlinger Elisabeth, Zwerger Michael, Wandel Annika, Neuber Laura Maria, Heilmeier Bernhard, Fichtner Regina, Mirbeth Carina, Herr Wolfgang, Thomas Simone

Abstract excerpt

HLA-DPB1 antigens are mismatched in about 80% of allogeneic hematopoietic stem cell transplantations from HLA 10/10 matched unrelated donors and were shown to be associated with a decreased risk of leukemia relapse. We recently developed a reliable in vitro method to generate HLA-DPB1 mismatch-reactive CD4 T-cell clones from allogeneic donors. Here, we isolated HLA-DPB1 specific T cell receptors (TCR DP) and used...

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Identifiers

PMID: 32443793
DOI: 10.3390/cells9051264
PMCID: PMC7290340

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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