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Article

Molecular reconstruction of a fungal genetic code alteration.

RNA biology - 1 Jun 2013

Mateus Denisa D, Paredes João A, Español Yaiza, Ribas de Pouplana Lluís, Moura Gabriela R, Santos Manuel A S

Abstract excerpt

Fungi of the CTG clade translate the Leu CUG codon as Ser. This genetic code alteration is the only eukaryotic sense-to-sense codon reassignment known to date, is mediated by an ambiguous serine tRNA (tRNACAG(Ser)), exposes unanticipated flexibility of the genetic code and raises major questions about its selection and fixation in this fungal lineage. In particular, the origin of the tRNACAG(Ser) and the...

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Identifiers

PMID: 23619021
DOI: 10.4161/rna.24683
PMCID: PMC4111736

Genes

CGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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