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Article

Reversion of a fungal genetic code alteration links proteome instability with genomic and phenotypic diversification.

Proceedings of the National Academy of Sciences of the United States of America - 2 Jul 2013

Bezerra Ana R, Simões João, Lee Wanseon, Rung Johan, Weil Tobias, Gut Ivo G, Gut Marta, Bayés Mónica, Rizzetto Lisa, Cavalieri Duccio, Giovannini Gloria, Bozza Silvia, Romani Luigina, Kapushesky Misha, Moura Gabriela R, Santos Manuel A S

Abstract excerpt

Many fungi restructured their proteomes through incorporation of serine (Ser) at thousands of protein sites coded by the leucine (Leu) CUG codon. How these fungi survived this potentially lethal genetic code alteration and its relevance for their biology are not understood. Interestingly, the hum...

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Identifiers

PMID: 23776239
DOI: 10.1073/pnas.1302094110
PMCID: PMC3704024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23776239-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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