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Article

Selective advantages created by codon ambiguity allowed for the evolution of an alternative genetic code in Candida spp.

Molecular microbiology - 1 Feb 1999

Santos M A, Cheesman C, Costa V, Moradas-Ferreira P, Tuite M F

Abstract excerpt

Several species of the genus Candida decode the standard leucine CUG codon as serine. This and other deviations from the standard genetic code in both nuclear and mitochondrial genomes invalidate the notion that the genetic code is frozen and universal and prompt the questions 'why alternative genetic codes evolved and, more importantly, how can an organism survive a genetic code change?' To address these two...

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PMID: 10048036
DOI: 10.1046/j.1365-2958.1999.01233.x

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