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Article

Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice.

Circulation - 21 May 2013

Majmudar Maulik D, Keliher Edmund J, Heidt Timo, Leuschner Florian, Truelove Jessica, Sena Brena F, Gorbatov Rostic, Iwamoto Yoshiko, Dutta Partha, Wojtkiewicz Gregory, Courties Gabriel, Sebas Matt, Borodovsky Anna, Fitzgerald Kevin, Nolte Marc W, Dickneite Gerhard, Chen John W, Anderson Daniel G, Swirski Filip K, Weissleder Ralph, Nahrendorf Matthias

Abstract excerpt

BACKGROUND: Exaggerated and prolonged inflammation after myocardial infarction (MI) accelerates left ventricular remodeling. Inflammatory pathways may present a therapeutic target to prevent post-MI heart failure. However, the appropriate magnitude and timing of interventions are largely unknown,...

Read the complete abstract on PubMed

Topics

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Share to Atherosclerosis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Therapy

Share to Monocytes

Share to Myocardial Infarction

Share to Random Allocation

Share to Receptors, CCR2

Share to Wound Healing

Source

Open in PubMed Open full text

Identifiers

PMID: 23616627
DOI: 10.1161/CIRCULATIONAHA.112.000116
PMCID: PMC3661714

Genes

MPO
CCR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23616627-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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