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Article

Disruption of the Ugt1 Locus in Mice Resembles Human Crigler-Najjar Type I Disease

8 Jan 2008

Abstract excerpt

The 9 UDP-glucuronosyltranferases (UGTs) encoded by the UGT1 locus in humans are key enzymes in the metabolism of most drugs as well as endogenous substances such as bile acids, fatty acids, steroids, hormones, neurotransmitters, and bilirubin. Severe unconjugated hyperbilirubinemia in humans that suffer from Crigler-Najjar type I disease results from lesions in the UGT1A1 gene and is often fatal. To examine the...

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PMID: 18180294
DOI: 10.1074/jbc.m709244200

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Disruption of the Ugt1 Locus in Mice Resembles Human Crigler-Najjar Type I DiseasePMID 18180294Read ↗

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