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The Gdac1 locus modifies spontaneous and Salmonella-induced colitis in mice deficient in either Gpx2 or Gpx1 gene.

Free radical biology & medicine - 1 Dec 2013

Steven Esworthy R, Kim Byung-Wook, Wang Yufeng, Gao Qiang, Doroshow James H, Leto Thomas L, Chu Fong-Fong

Abstract excerpt

We previously identified the Gdac1 (Gpx-deficiency-associated colitis 1) locus, which influences the severity of spontaneous colitis in Gpx1- and Gpx2-double-knockout (Gpx1/2-DKO) mice. Congenic Gpx1/2-DKO mice in the 129S1/SvImJ (129) background but carrying the Gdac1(B6) allele have milder spontaneous colitis than 129 Gpx1/2-DKO mice carrying the Gdac1(129) allele. Here, we evaluated the effect of the Gdac1(B6)...

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Identifiers

PMID: 24090658
DOI: 10.1016/j.freeradbiomed.2013.09.013
PMCID: PMC3875339

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