Article
Variation in the ICAM1 gene is not associated with severe malaria phenotypes.
Genes and immunity - 1 Jul 2008
Fry A E, Auburn S, Diakite M, Green A, Richardson A, Wilson J, Jallow M, Sisay-Joof F, Pinder M, Griffiths M J, Peshu N, Williams T N, Marsh K, Molyneux M E, Taylor T E, Rockett K A, Kwiatkowski D P
Abstract excerpt
Evidence from autopsy and in vitro binding studies suggests that adhesion of erythrocytes infected with Plasmodium falciparum to the human host intercellular adhesion molecule (ICAM)-1 receptor is important in the pathogenesis of severe malaria. Previous association studies between polymorphisms in the ICAM1 gene and susceptibility to severe malarial phenotypes have been inconclusive and often contradictory. We...
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