Article
DNA sequence variation and haplotype structure of the ICAM1 and TNF genes in 12 ethnic groups of India reveal patterns of importance in designing association studies.
Annals of human genetics - 1 Nov 2004
Sengupta S, Farheen S, Mukherjee N, Dey B, Mukhopadhyay B, Sil S K, Prabhakaran N, Ramesh A, Edwin D, Usha Rani M V, Mitra M, Mahadik C T, Singh S, Sehgal S C, Majumder P P
Abstract excerpt
We have examined the patterns of DNA sequence variation in and around the genes coding for ICAM1 and TNF, which play functional and correlated roles in inflammatory processes and immune cell responses, in 12 diverse ethnic groups of India. We aimed to (a) quantify the nature and extent of the variation, and (b) analyse the observed patterns of variation in relation to population history and ethnic background. At...
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