Article

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxification

2026-02-21

Abstract excerpt

A ubiquitous class of non-heme Fe(II) enzymes, the persulfide dioxygenases (PDOs), provide protection against hydrogen sulfide (H2S) poisoning. The PDO in humans is a single-domain enzyme, while bacterial PDOs, such as CstB of Staphylococcus aureus, are often fused to a sulfurtransferase (rhodanese) module. Canonical PDOs cleave the S-S bond of glutathione persulfide (GSSH) to produce GSH and sulfite (SO32–). In c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f1b1ddeb-cc72-58dd-be2c-a212eec97bc8
DOI: 10.64898/2026.02.20.707092

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Self-S-sulfonation in a bacterial persulfide dioxygenase mediates thiol persulfide detoxificationDOI 10.64898/2026.02.20.707092Read

Conformational analysis and chemical reactivity of the multidomain sulfurtransferase, Staphylococcus aureus CstA.Semantic proximity Read

Structural and biochemical analyses indicate that a bacterial persulfide dioxygenase-rhodanese fusion protein functions in sulfur assimilation.Semantic proximity Read

Characterization of an NADH-dependent persulfide reductase from Shewanella loihica PV-4: implications for the mechanism of sulfur respiration via FAD-dependent enzymes.Semantic proximity Read

Staphylococcus aureus sqr Encodes a Type II Sulfide:Quinone Oxidoreductase and Impacts Reactive Sulfur Speciation in Cells.Semantic proximity Read

Hydrogen Sulfide and Reactive Sulfur Species Impact Proteome S -Sulfhydration and Global Virulence Regulation in Staphylococcus aureusSemantic proximity Read

Mechanism-based inhibition of human persulfide dioxygenase by γ-glutamyl-homocysteinyl-glycine.Semantic proximity Read

Rhodanese Rdl2 produces reactive sulfur species to scavenge hydroxyl radical and protect mitochondriaSemantic proximity Read

Bacterial microcompartments for isethionate desulfonation in the taurine-degrading human-gut bacterium <i>Bilophila wadsworthia</i>Semantic proximity Read

Thiosulfate sulfurtransferase-like domain-containing 1 protein interacts with thioredoxin.Semantic proximity Read

Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases.Semantic proximity Read

Mutational analysis of sulfite reductase hemoprotein reveals the mechanism for coordinated electron and proton transfer.Semantic proximity Read

Why do bacteria use so many enzymes to scavenge hydrogen peroxide?Semantic proximity Read