Article
Molecular dissection of mutations in the Bacillus subtilis spore photoproduct lyase gene which affect repair of spore DNA damage caused by UV radiation.
Journal of bacteriology - 1 Aug 1995
Fajardo-Cavazos P, Nicholson W L
Abstract excerpt
In response to UV irradiation, Bacillus subtilis spore DNA accumulates the unique thymine dimer 5-thyminyl-5,6-dihydrothymine, or spore photoproduct (SP). SP is broken down into monomers during spore germination by the product of the spl gene which has been proposed to encode the enzyme SP lyase....
Topics
- Alleles
- Amino Acid Sequence
- Bacillus subtilis
- Base Sequence
- DNA Damage
- DNA Repair
- DNA, Bacterial
- Deoxyribodipyrimidine Photo-Lyase
- Gene Expression Regulation, Bacterial
- Models, Genetic
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Proteins
- Spores, Bacterial
- Ultraviolet Rays