Article
Influence of class I and II HLA alleles on inhibitor development in severe haemophilia A patients from the south of Brazil.
Haemophilia : the official journal of the World Federation of Hemophilia - 1 May 2012
De Barros M F, Herrero J C M, Sell A M, De Melo F C, Braga M A, Pelissari C B, Machado J, De Souza Schiller S, De Souza Hirle L, Visentainer J E L
Abstract excerpt
Congenital haemophilia A is a chromosome-linked recessive disorder caused by the deficiency or reduction of factor VIII (FVIII) pro-coagulant activity. During treatment, some patients develop alloantibodies (FVIII inhibitors) that neutralize the action of exogenously administered FVIII. Currently, the presence of these inhibitors is the most serious adverse event found in replacement therapy. Some studies have...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.