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Article

Frequency of intron 1 and 22 inversions of <i>factor VIII</i> gene in Mexican patients with severe hemophilia A

8 Jan 2007

Abstract excerpt

Hemophilia A (HA) is one of the most common inherited bleeding disorders caused by FVIII gene mutations. Inversion of intron 22 (inv22) originates 50% of cases of severe HA and is a major risk factor for inhibitor development. Inversion of intron 1 (inv1) has been reported to occur in 2-3% of severe HA patients. We studied both inversions to determine their frequencies in Mexican patients with severe HA and to...

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PMID: 17211847
DOI: 10.1002/ajh.20865

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