Article
The pre-mRNA retention and splicing complex controls tRNA maturation by promoting TAN1 expression.
Nucleic acids research - 1 Jun 2013
Zhou Yang, Chen Changchun, Johansson Marcus J O
Abstract excerpt
The conserved pre-mRNA retention and splicing (RES) complex, which in yeast consists of Bud13p, Snu17p and Pml1p, is thought to promote nuclear retention of unspliced pre-mRNAs and enhance splicing of a subset of transcripts. Here, we find that the absence of Bud13p or Snu17p causes greatly reduced levels of the modified nucleoside N(4)-acetylcytidine (ac(4)C) in tRNA and that a lack of Pml1p reduces ac(4)C...
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