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Article

ApoE4 disrupts sterol and sphingolipid metabolism in Alzheimer's but not normal brain.

Neurobiology of aging - 1 Apr 2009

Bandaru Veera Venkata Ratnam, Troncoso Juan, Wheeler David, Pletnikova Olga, Wang Jessica, Conant Kathy, Haughey Norman J

Abstract excerpt

The epsilon 4 allele of ApoE is associated with an earlier onset and faster progression of Alzheimer's disease in patients with the familial form of this neurodegenerative condition. Although ApoE4 has been repeatedly associated with altered sphingomyelin and cholesterol levels in tissue culture and rodent models, there has not been a direct quantification of sphingomyelin or sterol levels in the brains of...

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Identifiers

PMID: 17888544
DOI: 10.1016/j.neurobiolaging.2007.07.024
PMCID: PMC2758772

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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