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Article

Molecular analysis of the site for 2-arachidonylglycerol (2-AG) on the β₂ subunit of GABA(A) receptors.

Journal of neurochemistry - 1 Jul 2013

Baur Roland, Kielar Marie, Richter Lars, Ernst Margot, Ecker Gerhard F, Sigel Erwin

Abstract excerpt

2-arachidonyl glycerol (2-AG) allosterically potentiates GABA(A) receptors via a binding site located in transmembrane segment M4 of the β₂ subunit. Two amino acid residues have been described that are essential for this effect. With the aim to further describe this potential drug target, we perf...

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Identifiers

PMID: 23600744
DOI: 10.1111/jnc.12270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23600744-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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