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Article

Mechanism of group IVA cytosolic phospholipase A(2) activation by phosphorylation.

The Journal of biological chemistry - 17 Oct 2003

Das Sudipto, Rafter John D, Kim Kwang Pyo, Gygi Steven P, Cho Wonhwa

Abstract excerpt

Group IVA cytosolic phospholipase A2 (cPLA2) has been shown to play a critical role in the agonist-induced release of arachidonic acid. To understand the mechanism by which phosphorylation of Ser505 and Ser727 activates cPLA2, we systematically analyzed the effects of S505A, S505E, S727A, S727E, S505A/S727A, S505A/S727E, and S505E/S727E mutations on its enzyme activity and membrane affinity. In vitro membrane...

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PMID: 12885780
DOI: 10.1074/jbc.M304897200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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