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Article

Benzodiazepines modulate GABAA receptors by regulating the preactivation step after GABA binding.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 25 Apr 2012

Gielen Marc C, Lumb Michael J, Smart Trevor G

Abstract excerpt

GABA(A) receptors (GABA(A)Rs) composed of αβγ subunits are allosterically modulated by the benzodiazepines (BDZs). Agonists at the BDZ binding site potentiate submaximal GABA responses by increasing the apparent affinity of GABA(A)Rs for GABA. Although BDZs were initially thought to affect the binding of GABA agonists, recent studies suggest an effect on receptor gating; however, the involvement of preactivation...

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Identifiers

PMID: 22539833
DOI: 10.1523/JNEUROSCI.5663-11.2012
PMCID: PMC6703631

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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