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Article

Association study of GSK3 gene polymorphisms with schizophrenia and clozapine response.

Psychopharmacology - 1 Oct 2008

Souza Renan P, Romano-Silva Marco A, Lieberman Jeffrey A, Meltzer Herbert Y, Wong Albert H C, Kennedy James L

Abstract excerpt

RATIONALE: A number of human and animal studies implicate GSK3 in the pathophysiology and genetics of schizophrenia. In general, the data suggest that phosphorylation levels of GSK3beta are reduced in schizophrenia, resulting in increased GSK3beta activity. Since GSK3beta regulation is altered in schizophrenia, polymorphic variation in this gene may affect susceptibility to schizophrenia or treatment response....

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PMID: 18500637
DOI: 10.1007/s00213-008-1193-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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