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Article

OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.

Cancer research - 1 Jan 2010

Adamson David C, Shi Qun, Wortham Matthew, Northcott Paul A, Di Chunhui, Duncan Christopher G, Li Jianjun, McLendon Roger E, Bigner Darell D, Taylor Michael D, Yan Hai

Abstract excerpt

OTX2 is a developmentally regulated transcription factor involved in early morphogenesis of the central nervous system. This gene is amplified and overexpressed in medulloblastoma cell lines, but the nature and extent of its genetic alterations in primary tumors have not been evaluated. Analysis...

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Source

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Identifiers

PMID: 20028867
DOI: 10.1158/0008-5472.CAN-09-2331
PMCID: PMC2943736

Genes

OTX2
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20028867-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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OTX2 is critical for the maintenance and progression of Shh-independent medulloblastomas.PMID 20028867Read ↗

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