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Article

Analysis by metadynamics simulation of binding pathway of influenza virus M2 channel blockers.

Microbiology and immunology - 1 Jan 2018

Sakai Yuri, Kawaguchi Atsushi, Nagata Kyosuke, Hirokawa Takatsugu

Abstract excerpt

M2 protein of influenza A virus is a proton channel spanning the viral envelope. Activity of this proton channel is required for uncoating of viral particles and equilibrating the pH across the trans Golgi apparatus, which prevents conformational change in hemagglutinin. Amantadine, an anti-influenza A virus drug, inhibits M2 proton channel activity by binding to the channel pore; however, most currently...

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PMID: 29210473
DOI: 10.1111/1348-0421.12561

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