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Article

Null mutation of alpha1D Ca2+ channel gene results in deafness but no vestibular defect in mice.

Journal of the Association for Research in Otolaryngology : JARO - 1 Jun 2004

Dou Hongwei, Vazquez Ana E, Namkung Yoon, Chu Hanqi, Cardell Emma Lou, Nie Liping, Parson Susan, Shin Hee-Sup, Yamoah Ebenezer N

Abstract excerpt

Multiple Ca2+ channels confer diverse functions to hair cells of the auditory and vestibular organs in the mammalian inner ear. We used gene-targeting technology to generate alpha1D Ca2+ channel-deficient mice to determine the physiological role of these Ca2+ channels in hearing and balance. Analyses of auditory-evoked brainstem recordings confirmed that alpha1D-/- mice were deaf and revealed that heterozygous...

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Identifiers

PMID: 15357422
DOI: 10.1007/s10162-003-4020-3
PMCID: PMC2538408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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