A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish.

doi:10.1016/j.bbrc.2024.149551

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Article

A pH imbalance is linked to autophagic dysregulation of inner ear hair cells in Atp6v1ba-deficient zebrafish.

Biochemical and biophysical research communications - 5 Mar 2024

Ikeuchi Mayo, Inoue Masanori, Miyahara Hiroaki, Sebastian Wulan Apridita, Miyazaki Shuya, Takeno Takashi, Kiyota Kyoko, Yano Shinji, Shiraishi Hiroshi, Shimizu Nobuyuki, Hanada Reiko, Yoshimura Akihiko, Ihara Kenji, Hanada Toshikatsu

Abstract excerpt

V-ATPase is an ATP hydrolysis-driven proton pump involved in the acidification of intracellular organelles and systemic acid-base homeostasis through H+ secretion in the renal collecting ducts. V-ATPase dysfunction is associated with hereditary distal renal tubular acidosis (dRTA). ATP6V1B1 encodes the B1 subunit of V-ATPase that is integral to ATP hydrolysis and subsequent H+ transport. Patients with pathogenic...

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