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Article

β5i subunit deficiency of the immunoproteasome leads to reduced Th2 response in OVA induced acute asthma.

PloS one - 1 Jan 2013

Volkov Anton, Hagner Stefanie, Löser Stephan, Alnahas Safa, Raifer Hartmann, Hellhund Anne, Garn Holger, Steinhoff Ulrich

Abstract excerpt

The immunoproteasome subunit β5i has been shown to play an important role in Th1/Th17 driven models of colitis and arthritis. However, the function of β5i in Th2 dependent diseases remains enigmatic. To study the role of β5i in Th2-driven pathology, β5i knockout (KO) and control mice were tested in different models of experimental allergic asthma. β5i-deficient mice showed reduced OVA/Alum- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23593249
DOI: 10.1371/journal.pone.0060565
PMCID: PMC3617144

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