Article
A Mouse Model of Ovalbumin-Induced Airway Allergy Exhibits Altered Localization of SARS-CoV-2-Susceptible Cells in the Lungs, Which Reflects Omicron BA.5 Infection Dynamics, Viral Mutations, and Immunopathology.
Microbiology and immunology - 1 Jan 2025
Iketani Takao, Miyazaki Kaya, Iwata-Yoshikawa Naoko, Sakai Yusuke, Shiwa-Sudo Nozomi, Ozono Seiya, Asanuma Hideki, Hasegawa Hideki, Suzuki Tadaki, Nagata Noriyo
Abstract excerpt
Asthma, an allergic disease of the airways, is a risk factor for severity of common respiratory viral infections; however, the relationship between asthma and severity in COVID-19 remains unclear. Here, we examined the effects of SARS-CoV-2 (Omicron BA.5 strain) infection in a mouse model of airway allergy. First, stimulation of allergic mice with OVA resulted in the appearance of ACE2-negative mucus-secreting...
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