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The Anti-Asthmatic Immune Mechanisms of <em>Mt.b </em>ESAT6-Fc Fusion Protein via Intranasal Immunization in Murine Allergic Asthma

2024-11-07

Abstract excerpt

Currently, therapeutic Fc-fusion protein is used for treating disease. ESAT6 (6-kDa early secretory antigenic target), secreted by Mycobacterium tuberculosis, is involved in immune regulation. Administered via intranasal immunization, ESAT6-Fc fusion protein significantly alleviated allergic airway inflammation and mucus hypersecretion, reduced the proportions of Th2 cells, Th17 cells and eosinophils with no obser...

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Literature Corpus work
1733f0c0-ab4e-5683-87e5-7669b58da9ca
DOI
10.20944/preprints202411.0404.v1
Open publication

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