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Article

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.

PloS one - 1 Jan 2013

Hodgson Myles C, Vanostran Garrett, Alghamdi Sarah, Poppiti Robert J, Agoulnik Alexander I, Agoulnik Irina U

Abstract excerpt

Androgen receptor (AR) is commonly expressed in both the epithelium of normal mammary glands and in breast cancers. AR expression in breast cancers is independent of estrogen receptor alpha (ERα) status and is frequently associated with overexpression of the ERBB2 oncogene. AR signaling effects o...

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Share to Estrogen Receptor alpha
Share to Gene Knockout Techniques
Share to Mammary Glands, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Neoplasms, Experimental

Share to Receptor, ErbB-2

Share to Receptor, ErbB-3

Share to Receptors, Androgen

Share to Receptors, Progesterone

Source

Open in PubMed Open full text

Identifiers

PMID: 23593223
DOI: 10.1371/journal.pone.0060455
PMCID: PMC3620158

Genes

ERBB2
FOXA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23593223-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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