Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor.

The Journal of experimental medicine - 15 Dec 2003

Yeh Shuyuan, Hu Yueh-Chiang, Wang Peng-Hui, Xie Chao, Xu Qingquan, Tsai Meng-Yin, Dong Zhihong, Wang Ruey-Sheng, Lee Ting-Hein, Chang Chawnshang

Abstract excerpt

Phenotype analysis of female mice lacking androgen receptor (AR) deficient (AR-/-) indicates that the development of mammary glands is retarded with reduced ductal branching in the prepubertal stages, and fewer Cap cells in the terminal end buds, as well as decreased lobuloalveolar development in adult females, and fewer milk-producing alveoli in the lactating glands. The defective development of AR-/- mammary...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Insulin-Like Growth Factor I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mammary Glands, Animal

Share to Mitogen-Activated Protein Kinases

Share to Morphogenesis

Share to Receptor, IGF Type 1

Share to Receptors, Androgen

Share to Receptors, Estrogen

Source

Open in PubMed Open full text

Identifiers

PMID: 14676301
DOI: 10.1084/jem.20031233
PMCID: PMC2194158

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Abnormal mammary gland development and growth retardation in female mice and MCF7 breast cancer cells lacking androgen receptor.PMID 14676301Read ↗

Premature ovarian failure in androgen receptor-deficient miceSemantic proximity Read ↗

Female mice haploinsufficient for an inactivated androgen receptor (AR) exhibit age-dependent defects that resemble the AR null phenotype of dysfunctional late follicle development, ovulation, and fertility.Semantic proximity Read ↗

Androgen resistance in female mice increases susceptibility to DMBA-induced mammary tumors.Semantic proximity Read ↗

Reduced androgen receptor expression accelerates the onset of ERBB2 induced breast tumors in female mice.Semantic proximity Read ↗

Roles of androgen receptor in male and female reproduction: lessons from global and cell-specific androgen receptor knockout (ARKO) mice.Semantic proximity Read ↗

Development and Characterization of Cell-Specific Androgen Receptor Knockout Mice.Semantic proximity Read ↗

Ventral prostate and mammary gland phenotype in mice with complete deletion of the ERβ gene.Semantic proximity Read ↗

Human androgen deficiency: insights gained from androgen receptor knockout mouse modelsSemantic proximity Read ↗

An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation.Semantic proximity Read ↗

Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation.Semantic proximity Read ↗

Increased prostate cell proliferation and loss of cell differentiation in mice lacking prostate epithelial androgen receptor.Semantic proximity Read ↗

A floxed allele of the androgen receptor gene causes hyperandrogenization in male miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.