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A Sleeping Beauty screen reveals NF-kB activation in CLL mouse model

16 Apr 2013

Abstract excerpt

TCL1 oncogene is overexpressed in aggressive form of human chronic lymphocytic leukemia (CLL) and its dysregulation in mouse B cells causes a CD5-positive leukemia similar to the aggressive form of human CLLs. To identify oncogenes that cooperate with Tcl1, we performed genetic screen in Eμ-TCL1 mice using Sleeping Beauty transposon-mediated mutagenesis. Analysis of transposon common insertion sites identified 7...

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PMID: 23591791
DOI: 10.1182/blood-2013-02-486035

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