Article
Sleeping Beauty Screen Identifies RREB1 and Other Genetic Drivers in Human B-cell Lymphoma.
Molecular cancer research : MCR - 1 Feb 2019
Rahrmann Eric P, Wolf Natalie K, Otto George M, Heltemes-Harris Lynn, Ramsey Laura B, Shu Jingmin, LaRue Rebecca S, Linden Michael A, Rathe Susan K, Starr Timothy K, Farrar Michael A, Moriarity Branden S, Largaespada David A
Abstract excerpt
Follicular lymphoma and diffuse large B-cell lymphoma (DLBCL) are the most common non-Hodgkin lymphomas distinguishable by unique mutations, chromosomal rearrangements, and gene expression patterns. Here, it is demonstrated that early B-cell progenitors express 2',3'-cyclic-nucleotide 3' phosphodiesterase (CNP) and that when targeted with Sleeping Beauty (SB) mutagenesis, Trp53R270H mutation or Pten loss gave...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.