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Article

Association between the genetic polymorphisms of glutathione S-transferase (GSTM1 and GSTT1) and the clinical manifestations in sickle cell anemia.

Blood cells, molecules & diseases - 1 Aug 2013

de Oliveira Filho Romério Alencar, Silva Géssyka Jerônimo, de Farias Domingos Igor, Hatzlhofer Betânia Lucena Domingues, da Silva Araújo Aderson, de Lima Filho José Luiz, Bezerra Marcos André Cavalcanti, Martins Danyelly Bruneska Gondim, de Araújo Rosângela Ferreira Frade

Abstract excerpt

The hereditary deficiency of antioxidant enzymes when associated with sickle cell anemia (SCA) further contributes to the oxidation of hemoglobin S, which increases the formation of degradation products of this hemoglobin. The glutathione S transferases play an important role in the conjugation of glutathione to endogenous products of peroxidation of lipids and protect cells from the deleterious effects of...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23590899
DOI: 10.1016/j.bcmd.2013.03.003

Genes

GSTM1
GSTT1

Provenance

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