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Article

Relationship between oxidative stress, glutathione S-transferase polymorphisms and hydroxyurea treatment in sickle cell anemia.

Blood cells, molecules & diseases - 15 Jun 2011

Silva Danilo Grünig Humberto, Belini Junior Edis, Torres Lidiane de Souza, Ricci Júnior Octávio, Lobo Clarisse de Castro, Bonini-Domingos Claudia Regina, de Almeida Eduardo Alves

Abstract excerpt

This study evaluated the oxidative stress and antioxidant capacity markers in sickle cell anemia (SCA) patients with and without treatment with hydroxyurea. We assessed GSTT1, GSTM1 and GSTP1 polymorphisms in patients and a control group. The study groups were composed of 48 subjects without hemoglobinopathies and 28 SCA patients, 13 treated with HU [SCA (+HU)], and 15 SCA patients not treated with HU [SCA...

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Share to Anemia, Sickle Cell
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21489839
DOI: 10.1016/j.bcmd.2011.03.004

Genes

CAT
GSTP1
GSTM1
GSTT1

Provenance

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