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Article

Evaluating glutathione S-transferase (GST) null genotypes (GSTT1 and GSTM1) as a potential biomarker of predisposition for developing leukopenia.

International journal of laboratory hematology - 1 Feb 2010

Goncalves M S, Moura Neto J P, Souza C L, Melo P, Reis M G

Abstract excerpt

Glutathione S-transferase (GST) enzymes protect cells against xenobiotics and oxidative stress products through an electrophilic conjugation process. We investigated the theta (GSTT1) and mu (GSTM1) null genotypes in a group of leukopenic subjects and normal subjects from Northeast Brazil, evaluating their use as biomarkers of susceptibility for developing leukopenia. In a sample-based case-control study, we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19555437
DOI: 10.1111/j.1751-553X.2009.01169.x

Genes

GSTM1
GSTT1

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